MORPHOFUNCTIONAL CHANGES OF STAGE AND PRODUCTIVITY OF THE SEMINAL GLANDS MALE RATS UNDER THE INFLUENCE OF HEAVY METALS

  • Ju. V. Eschenko Zaporizhzhya National University
  • V. D. Bovt Zaporizhzhya National University
  • М. D. Romanova Zaporizhzhya National University
Keywords: fertility, spermatozoids, heavy metals, helatable metals, Cu, Zn, Mg

Abstract

Helatable elements, such as Zn, Mg, and Cu are important for reproduction health. This metals has intensively studied, there deficiency leads to gonadal dysfunction, decreases testicular weight and causes shrinkage of seminiferous tubules.

Zn, Mg, and Cu are necessary for reproduction, because the gonads are the most rapidly growing tissues in body and vital enzymes involved in nuclear acid and protein synthesis are metal enzymes.

These three cations (Zn, Mg, and Cu) stimulate or inhibit progressive motility of spermatozoids, depending of the concentration of each. If concentrations of metals are high, these elements individually or jointly impair fertility among the patricians with normal sperm density.

We studied the effects of heavy metals on seminal male rat’s glands during the period of postnatal ontogenesis, and contents of helatable metals (Zn, Mg, and Cu) in spermatozoids. It was investigated with the help histological, morphometric and statistical research methods.

The data indicate that, in the process of gametogenesis is the most vulnerable link in the formation stage spermatids. There was a decrease index of spermatogenesis and the index of relaxation that testifies about decrease of functional activity of the testicular. Revealed a decrease in the concentration of spermatozoids in the ejaculate, and their viability.

There are conclusion: heavy metals negatively affect the morphofunctional state of gonads in male rats, causing deformation of the parenchyma and the stroma of the testicles, and leads to disruption of spermatogenesis; the influence of heavy metals on the body of rats causes the change of spermatozoa in the form of changes in the form of the head and its reduction, the total reduction in the neck and the increase in tail part of the sperm, which significantly impairs the function of fertility; the index of spermatogenesis and the index of relaxation under the influence of heavy metals are reduced, which causes a decrease in the functional activity of the testicles of rats; the productivity of the spermatic glands is reduced by the action of heavy metals, which manifests itself in reducing the concentration of sperm in the ejaculate, and also reduces their viability; the negative influence of heavy metals on the ratio of the content of chelating metals (Zn, Mg, Cu), the content of Zn, Mg decreases and the content of Cu increases, which uniquely disrupts the process of spermatogenesis, which in turn leads to a decrease in the function of fertility.

References

ЛІТЕРАТУРА
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REFERENCES
1. Keel B. A. Within- and between- subject variation in semen parameters in infertile men and normal semen donors. Fertil. Steril., 2006. 128 p.
2. Within- subject variation of seminal parameters in men with infertile marriages / Francavillia F. еt all. Int. J. Androl., 2007. Vol. 30. 174 p.
3. Influence of analytical and biological variation on the clinical interpretation of seminal parameters / Castilla J. A. еt all. Hum. Reprod., 2006. 847 p.
4. Zalupus R. K., Koropatnich J. Cellular and molecular biology of metal. New York: CRC Press, 2010. 442 p.
5. Єshhenko Ju. V. Stres і metabolіzm metalіv. Zaporіzhzhja: ZNU, 2010. 268 s.
6. Jewuier A. M. Semen analysis: a new manual and its application to the understanding of semen and its pathology. Asian J. Andrology, 2010. Vol. 12. 11 p
7. Tudor R., Zalewski P., Rathaike R. Zinc in health and chronic disease. J Nutr. Health Aging, 2005. Vol. 1. P. 31
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12. Taravati A., Tohidi F. Association between seminal plasma zinc level and astenozoospermia: a meta-analysis study. Andrologia, 2015. DOI: 10.1111/and.12494.
How to Cite
Eschenko, J. V., Bovt, V. D., & RomanovaМ. D. (1). MORPHOFUNCTIONAL CHANGES OF STAGE AND PRODUCTIVITY OF THE SEMINAL GLANDS MALE RATS UNDER THE INFLUENCE OF HEAVY METALS. Bulletin of Zaporizhzhia National University. Biological Sciences, (2), 49-55. Retrieved from http://journalsofznu.zp.ua/index.php/biology/article/view/96