Assessment of the biological effects of 4-hydrazinoquinoline derivatives

  • Y. I. Romanenko Donetsk National Medical University
  • O. O. Klimova Zaporizhzhya National University
  • O. A. Brazhko Zaporizhzhya National University
Keywords: quinoline, derivatives of 4-hydrazinoquinoline, biological activity, lipophilicity, acute toxicity, cytotoxicity, PASS prediction

Abstract

Lipophilicity, biological activity and acute toxicity are important indicators of the viability of drugs. These indicators primarily depend on the chemical structure of the compound, the diversity of functional groups and their quantity. Using ChemDraw, a combinatorial library was created and the lipophilicity and solubility of 4-hydrazinoquinoline oxo acid derivatives were studied. A lipophilic non-polar substance dissolves in the lipid layer of the cell membrane, and the higher the lipophilicity, the greater the ability to penetrate through the cell membrane into substances. In parallel, the solubility of the substances was determined. Virtual studies using PASS Online made it possible to predict biological activity for 4-hydrazinopochid quinoline and their analogues having a methyl group in the 2nd position of azaheterocycles (4-hydrazinoquinaldins). The LD50 value is one of the important characteristics of acute toxicity. The goals of studying acute toxicity are to determine the harmless, toxic, lethal doses of a substance, its ability to cumulate, and also the causes of death of animals. Acute toxicity of lithium (E)-2-(2-(2-methylquinolin-4-yl)hydrazinylidene)pentanedioate was experimentally investigated. The cytotoxic effect of the compounds was tested on cell division and cell growth of cucumber roots (kind «Konkurent»). The study of the growth-regulating activity of lithium (E)-2-(2-(2-methylquinolin-4-yl)hydrazinoylidene)pentanedioate showed that this salt is most active as a cytokine and is classified as a toxicological classification for low toxic substances. Studies on prokaryotes have shown that the pigment-stimulating ability is enhanced in proportion to the concentration of lithium (E)-2-(2-(2-methylquinolin-4-yl)hydrazinoylidene)pentanedioate in nutrient media for individual cultures.

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How to Cite
Romanenko, Y. I., Klimova, O. O., & Brazhko, O. A. (1). Assessment of the biological effects of 4-hydrazinoquinoline derivatives. Bulletin of Zaporizhzhia National University. Biological Sciences, (1), 53-61. https://doi.org/10.26661/2410-0943-2019-1-06